Do you mean to have affiliate links on your site or complete affiliate interface where all you do is sell someone's products?
Affiliate links/banners may work very good as a replacement to Adsense or YPN. If you find products directly related to your niche - you can generate some referral commissions which usually much higher than any PPC.
Affiliate interface I would stay away unless you are new to internet and this will be one of your first sites. As any website it will require a lot of promotion and you will be competing with hundreds if not thousands of other affiliates...
Take a TemplateMonster for example - they give you complete coded website if you like but there are about 50-60 thousands affiliates out there selling exactly the same stuff...
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